On Friday night, just before 11:00 pm, Regina Police responded to report of an injured man near the Royal Saskatchewan Museum.
When police arrived, two men were found to have sustained serious, life-threatening injuries and were both transported to hospital.
No suspects have been located at this time. The scene was held for investigation until just before 10:00 am Saturday.
No other information has been released as the investigation is ongoing.
Anyone with any information is asked to call Regina Police at 306-777-6500 or Crime Stoppers at 1-800-222-8477.